Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects

Table 2

Colonic myeloperoxidase (MPO) issue levels 1 week after intracolonic TNBS; effect of concomitant cephalothin (CLT).

Treatment (𝑛)	Mean ± SEM (units/mg)
1 wk veh + i-colo veh [23]	0.24±0.03
1 wk CLT + i-colo veh [23]	0.23±0.03
1 wk veh + i-colo TNBS [23]	0.56±0.09^a
1 wk CLT + i-colo TNBS [23]	0.29±0.04^b

One-week cephalothin treatment ((302 μmole) 126 mg/Kg/day, ip) was effective to attenuate colonic inflammation caused by intracolonic (ic) TNBS instillation, as measured by MPO activity. ^a𝑃<0.005 compared to 1-week veh + ic veh; ^b𝑃<0.005 compared to 1-week veh + ic TNBS).