Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects

Table 3

Colonic myeloperoxidase (MPO) issue levels after oral 4% DSS; effect of therapeutic ceftriaxone.

Treatment (𝑛)	Mean ± SEM (units/mg)
1 wk veh + oral H2O [4]	0.21±0.01
1 wk CTX + oral H2O [11]	0.17±0.03
1 wk veh + 4% DSS [4]	0.50±0.06^a
1 wk CTX + 4% DSS [4]	0.35±0.05^a

Ceftriaxone (200 mg/kg daily for 1 week), administered one week after initiation of colonic inflammation by oral 4% DSS in the drinking water, was ineffective to significantly reduce colonic inflammation, measured by MPO activity at day 14. ^a𝑃<0.005 compared to 1-week veh + oral H₂O.