Synaptic Conversion of Chloride-Dependent Synapses in Spinal Nociceptive Circuits: Roles in Neuropathic Pain
Figure 4
Symbolic representations for normal and aberrant chloride-dependent synapses. Excitatory and inhibitory synapses are denoted based upon the postsynaptic response. The Conversion Factor () (see (8)) and the chloride flux are shown for chloride-dependent synapses with normal and aberrant (denoted with asterisks) postsynaptic responses. (a) Excitatory neuron with excitatory postsynaptic response. (b) Inhibitory neuron with inhibitory postsynaptic response. (c) Inhibitory neuron with a converted chloride-dependent synapse. The aberrant excitatory response is denoted with an asterisk and an open triangle. Elevated chloride in the postsynaptic cell is denoted with yellow.
