Lumbar Facet Joint Compressive Injury Induces Lasting Changes in Local Structure, Nociceptive Scores, and Inflammatory Mediators in a Novel Rat Model
Figure 6
(a) Total dorsal horn TNF-alpha RNA. Sham control (gray, open surgery is performed as in the experimental group, but without facet joint compression) and the experimental group (black, open surgery followed by facet joint L5/L6 compression) during a time course (day 7, 14, and 28). Real-time PCR results were normalized by using -actin as an internal control. (b) Total dorsal horn TNF-alpha RNA. Experimental group in a time course (day 7, 14, and 28), left versus right sides of lumbar spinal dorsal horn. Real-time PCR results were normalized by using -actin as an internal control. (c) Total dorsal horn IL-1beta RNA. Sham control (gray, open surgery is performed as in the experimental group, but without facet joint compression) and the experimental group (black, open surgery followed by facet joint L5/L6 compression) during a time course (day 7, 14, and 28). Real-time PCR results were normalized by using -actin as an internal control. (d)Total dorsal horn IL-1beta RNA. Experimental group in a time course (day 7, 14, and 28), left versus right sides of lumbar spinal dorsal horn. Real-time PCR results were normalized by using -actin as an internal control.
