Pain Research and Treatment / 2012 / Article / Tab 1

Research Article

Peripheral Glutamate Receptors Are Required for Hyperalgesia Induced by Capsaicin

Table 1

Mean value of c-Fos-ir cells in the dorsal horn of L4-L5 2 h after s.c. injection of capsaicin, glutamate, and glutamate receptors antagonists with/without capsaicin. The value in each group was represented mean ± SEM obtained from at least 10 animals, and the difference of the means was analyzed with the Student’s t-test.

Group Ipsilateral Contralateral
I/II-layerIII IV-layerI/II-layerIII IV-layer

Vehicle60 ± 522 ± 812 ± 47 ± 2
Capsaicin(cap)489 ± 34*63 ± 1844 ±13
Glutamate283 ± 18*36 ± 519 ± 8

MK80179 ± 311 ± 733 ± 129 ± 5
CNQX70 ± 87 ± 314 ± 73 ± 2
CPCCOEt59 ± 86 ± 310 ± 46 ± 2
MCCG63 ± 105 ± 228 ± 115 ± 2
MSOP66 ± 165 ± 39 ± 45 ± 3

Cap + MK801227 ± 32#14 ± 48 ± 63 2
Cap + CNQX205 ± 40#11 ± 722 ± 123 ± 2
Cap + CPCCOEt236 ± 58#17 ± 1112 ± 74 ± 3
Cap + MCCG560 ± 8527 ± 1024 ± 93 ± 1
Cap + MSOP383 ± 2122 ± 318 ± 134 ± 1

*Significant difference at between vehicle and capsaicin, or glutamate-treated group. #Significant difference at P < 0.05 between capsaicin and capsaicin + MK801, or capsaicin + CNQX, or capsaicin + CPCCOEt-treated group.

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