Estrogen and Visceral Nociception at the Level of Primary Sensory Neurons
Figure 2
Proposed mechanism of estradiol effect on ATP-induced [Ca2+]i signaling in primary sensory neurons. ATP released by tissue damage acts on P2X3 receptor resulting in activation of the L-type voltage-gated calcium channel (VGCC). ERα activates mGluR2/3 which in turn activates Gi/o signaling resulting in inhibition of adenylate-cyclase (AC). Decreased cAMP concentration reduced PKA activation and decreased the conductance of the L-type VGCC.
