Review Article
Role of NHE1 in Nociception
Table 1
Characteristics of the Na+/H+ exchanger (NHE) family.
| | Common name (gene) | Distribution | Membrane
Localization | Function | Pathophysiology |
| | NHE1 (SLC9A1) | Ubiquitous | Plasma membrane | Cytosolic pH, cell volume, fluid secretion, cell shape, proliferation, migration | Ataxia, seizures, ischemia, reduced parotid gland secretion, pain | | NHE2 (SLC9A2) | Several tissues | Plasma membrane | Fluid secretion | Loss of acid secretion, reduced parotid gland secretion | | NHE3 (SLC9A3) | Kidney, intestines | Plasma membrane | Reabsorption of Na+ and | Diarrhea, tubular proteinuria, hypertension | | NHE4 (SLC9A4) | Stomach
Kidney | Plasma membrane | Cytosolic pH,
fluid secretion | Impaired gastric acid secretion | | NHE5 (SLC9A5) | Brain, testis, spleen, and
skeletal muscle | Plasma membrane | Cytosolic pH | Pain | | NHE6 (SLC9A6) | Ubiquitous | Endosomes | Organellar pH | X-linked mental retardation, epilepsy, ataxia | | NHE7 (SLC9A7) | Ubiquitous | Endosomes | Organellar pH | Unknown | | NHE8 (SLC9A8) | Ubiquitous | Endomembranes | Organellar pH | Unknown | | NHE9 (SLC9A9) | Ubiquitous | Endosomes | Organellar pH | Attention-deficit hyperactivity disorder, autism-spectrum disorder |
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