Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma: A Proof-of-Concept Study with Pilot Results

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left"> </td><td align="center">3-month percent disability</td><td align="center">3-month pain intensity</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left">Cortisol waking response</td><td align="center">0.24 (0.53)</td><td align="center">0.05 (0.88)</td></tr><tr><td align="left">Hair-normalized cortisol waking response </td><td align="center"><b>0.70 (0.04)</b></td><td align="center">0.23 (0.53)</td></tr><tr><td align="left">Mean daily cortisol</td><td align="center">0.19 (0.63)</td><td align="center">−0.01 (0.99)</td></tr><tr><td align="left">Hair-normalized mean daily cortisol</td><td align="center">−0.09 (0.83)</td><td align="center">0.25 (0.52)</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>
							The bolded values indicated statistically significant results.<br/></td></tr></table>

Pearson’s product-moment correlations between baseline (acute) cortisol variables and self-reported percent disability at 3-month followup.  

Pain Research and Treatment

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Table 3

Table 3: Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma: A Proof-of-Concept Study with Pilot Results 

Table 3 | Hair-Normalized Cortisol Waking Response as a Novel Biomarker of Hypothalamic-Pituitary-Adrenal Axis Activity following Acute Trauma: A Proof-of-Concept Study with Pilot Results 