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Pain Research and Treatment
Volume 2014, Article ID 513628, 7 pages
http://dx.doi.org/10.1155/2014/513628
Clinical Study

Comparison of Postoperative Analgesic Effect of Intrathecal Clonidine and Fentanyl Added to Bupivacaine in Patients Undergoing Cesarean Section: A Prospective Randomized Double-Blind Study

1Department of Anesthesiology, Faculty of Medicine, Qazvin University of Medical Sciences, Shahid Bahonar Boulevard, P.O. Box 34197/59811, Qazvin 3419759811, Iran
2Department of Obstetrics and Gynecology, Faculty of Medicine, Qazvin University of Medical Sciences, Shahid Bahonar Boulevard, P.O. Box 34197/59811, Qazvin 3419759811, Iran

Received 17 July 2013; Revised 18 November 2013; Accepted 3 December 2013; Published 4 February 2014

Academic Editor: Robert L. Barkin

Copyright © 2014 Marzieh Beigom Khezri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To compare the analgesic efficacy of intrathecal clonidine and fentanyl added to bupivacaine after cesarean section. Methods. Ninety patients scheduled for cesarean section under spinal anesthesia were randomly allocated to one of the three following groups to receive bupivacaine 10 mg combined with 75 µg clonidine (group C), bupivacaine 10 mg combined with 0.5 mL fentanyl (group F), and bupivacaine 10 mg combined with 0.5 mL distilled water (group P), intrathecally. The time to first analgesic request, analgesic requirement in the first 24 hours after surgery, sensory and motor blockade onset time, duration of sensory and motor blockade, the incidence of hypotension, ephedrine requirements, bradycardia, and hypoxemia were recorded. Results. The duration of anesthesia in clonidine group ( ) was longer compared to the placebo ( ) and fentanyl ( ) groups. This difference between group C versus F ( ) and P groups ( ) was significant. Similarly, the mean time to first analgesic request was also longer in group C ( ) than in groups F ( ) and P (  min). This difference between group C versus F ( ) and P groups ( ) was significant. Conclusion. Intrathecal clonidine 75 µg with bupivacaine prolonged the time to first analgesic request compared to fentanyl; however, the total analgesic consumption within the first 24 h postoperative was similar in fentanyl and clonidine groups following cesarean section. This trial is registered with ACTRN12611000909921 and ClinicalTrials.gov NCT01425658.