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This paper has been retracted as it is essentially identical in content with a previously published paper titled “Antinociceptive Tolerance to NSAIDs Microinjected into Dorsal Hippocampus” published by the same authors in BMC Pharmacology and Toxicology.

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  1. N. Tsiklauri, I. Nozadze, G. Gurtskaia, and M. G. Tsagareli, “Is hippocampus susceptible to antinociceptive tolerance to NSAIDs like the periaqueductal grey?” Pain Research and Treatment, vol. 2014, Article ID 654578, 8 pages, 2014.
Pain Research and Treatment
Volume 2014, Article ID 654578, 8 pages
Research Article

Is Hippocampus Susceptible to Antinociceptive Tolerance to NSAIDs Like the Periaqueductal Grey?

Department of Neurophysiology, Ivane Beritashvili Center for Experimental Biomedicine, 0160 Tbilisi, Georgia

Received 3 February 2014; Revised 6 March 2014; Accepted 21 March 2014; Published 9 April 2014

Academic Editor: Donald A. Simone

Copyright © 2014 Nana Tsiklauri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Emotional distress is the most undesirable feature of painful experience. Numerous studies have demonstrated the important role of the limbic system in the affective-motivational component of pain. The purpose of this paper was to examine whether microinjection of nonsteroidal anti-inflammatory drugs (NSAIDs), Clodifen, Ketorolac, and Xefocam, into the dorsal hippocampus (DH) leads to the development of antinociceptive tolerance in male rats. We found that microinjection of these NSAIDs into the DH induces antinociception as revealed by a latency increase in the tail-flick (TF) and hot plate (HP) tests compared to controls treated with saline into the DH. Subsequent tests on consecutive three days, however, showed that the antinociceptive effect of NSAIDs progressively decreased, suggesting tolerance developed to this effect of NSAIDs. Both pretreatment and posttreatment with the opioid antagonist naloxone into the DH significantly reduced the antinociceptive effect of NSAIDs in both pain models. Our data indicate that microinjection of NSAIDs into the DH induces antinociception which is mediated via the opioid system and exhibits tolerance.