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Pain Research and Treatment
Volume 2014, Article ID 850794, 7 pages
Clinical Study

Effect of Pregabalin and Dexamethasone on Postoperative Analgesia after Septoplasty

1Department of Anesthesiology and Reanimation, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey
2Department of Otorhinolaryngology, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, 14280 Bolu, Turkey

Received 30 January 2014; Accepted 5 April 2014; Published 24 April 2014

Academic Editor: Karel Allegaert

Copyright © 2014 Abdullah Demirhan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. The aim of this study was to explore effect of a combination of pregabalin and dexamethasone on pain control after septoplasty operations. Methods. In this study, 90 patients who were scheduled for septoplasty under general anesthesia were randomly assigned into groups that received either placebo (Group C), pregabalin (Group P), or pregabalin and dexamethasone (Group PD). Preoperatively, patients received either pregabalin 300 mg one hour before surgery, dexamethasone 8 mg intravenously during induction, or placebo according to their allocation. Postoperative pain treatment included tramadol and diclofenac sodium 30 minutes before the end of the operation. Numeric rating scale (NRS) for pain assessment, side effects, and consumption of tramadol, pethidine, and ondansetron were recorded. Results. The median NRS score at the postoperative 0 and the 2nd h was significantly higher in Group C than in Group P and Group PD ( for both). The 24 h tramadol and pethidine, consumptions were significantly reduced in Groups P and PD compared to Group C (). The incidence of blurred vision was significantly higher in Group PD compared to Group C within both 0–2 h and 0–24 h periods (, resp.). Conclusions. We conclude that administration of 300 mg pregabalin preoperatively may be an adequate choice for pain control after septoplasty. Addition of dexamethasone does not significantly reduce pain in these patients.