Palmitoylethanolamide in the Treatment of Failed Back Surgery Syndrome

Figure 2

Changes in pain intensity by VAS measurement. FBSS patients selected at baseline () received standard treatment comprising TPD + PGB for one month before surgery and showed a significant reduction immediately after surgery (). There was a significant increase in pain intensity after a mean time of 6.5 ± 2.5 months (range: 2–8 months) following surgery (). At this time (), patients were again given TPD + PGB for 3 months (up to ); um-PEA was added for the last two months ( to ). VAS reduction was statistically significant at each time ().