Incidence and Health Related Quality of Life of Opioid-Induced Constipation in Chronic Noncancer Pain Patients: A Prospective Multicentre Cohort Study
Table 3
OIC incidence at 6 months.
OIC Incidence at 6 months of follow-up
Variable
No Constipation
Constipation
value
Age, years
0.171
18-45
123 (24.3%)
28 (16.8%)
45-60
154 (30.4%)
60 (35.9%)
60-75
167 (32.9%)
54 (32.3%)
>75
63 (12.4%)
25 (15.0%)
Gender
Female
354 (69.8%)
134 (80.2%)
0.009
Male
153 (30.2%)
33 (19.8%)
BMI
27.33 (5.50)
26.87 (5.10)
0.357
Education level
0.562
No education
15 (3.0%)
4 (2.4%)
1-4 years (basic 1st cycle)
246 (48.6%)
94 (56.3%)
5-9 years (basic 2nd and 3rd cycles)
127 (25.1%)
36 (21.6%)
10-12 years (secondary)
61 (12.1%)
17 (10.2%)
More than 12 years (higher)
57 (11.3%)
16 (9.6%)
Opioid therapy
0.034
Yes
338 (72.8%)
126 (75.4%)
No
169 (80.5%)
41 (24.6%)
Analgesic Therapy
0.087
Non-opioid
168 (80.4%)
41 (24.6%)
Weak opioid
233 (71.9%)
91 (54.5%)
Strong opioid
104 (74.8%)
35 (21.0%)
Laxatives use
2 (100%)
51 (100%)
<0.001
Depressive disorder
102 (21.4%)
37 (24.0%)
0.504
OIC: opioid-induced constipation; BMI: body mass index. Data are presented as (%) except BMI which is presented as mean ± standard deviation. Proportions are calculated as column proportions. values are derived from (a) x2; (b) test comparisons.
