Review Article

Liposome Bupivacaine Compared to Plain Local Anesthetics to Reduce Postsurgical Pain: An Updated Meta-Analysis of Randomized Controlled Trials

Table 1

Summary of study characteristics included in analysis.

AuthorsYear of PublicationProceduresNumber treatmentTreatmentType of AnesthesiaPostoperative analgesiaMethod of extraction†

Amundson et. al [13]2017Total Knee Arthroplasty52/55Exparel 20 mL
(266mg) +100mL NS
120 mL (300mg) Ropivacaine
Spinal or
GA
Not standardizedText
Table

Barrington et. al [14]2016Total Knee Arthroplasty40/38Exparel 20 mL
(266mg) + 10mL NS
50mL 0.5% Ropivacaine
SpinalUnknownText
Table

Bramlett et. al [15]2012Total Knee Arthroplasty25/35Exparel 20 mL
(266mg) + 40mL NS
.50% Bupivacaine 30mL + 30ml NS
General1000mg Acetaminophen q tid
IV-PCA morphine – no basal rate
Oxycodone 5mg-10mg q 4-6h
Text
Table

Gasanova et. al [16]2015Open Total Abdominal
Hysterectomy
29/29Exparel 20 mL
(266mg) + 40mL NS
Bilateral TAP Bupivacaine 0.5% 20mL
GeneralHydromorphone 0.1 to 0.2mg IV until VAS <3
IV-PCA morphine 1mg bolus 5min lockout
Ketrolac IV 30mg
Acetaminophen 1 g PO q 6h
After 24hrs – Acetaminophen 1 g PO q 8h
Hydrocodone 5mg/Acetaminophen 325mg 1 to 2 tabs q6 as needed.
Text
Figure

Hutchins et. al [17]2015Robotic assisted hysterectomy28/30Exparel 10 mL
(266mg) + 20mL NS times 2 (bilateral)
0.25% Bupivacaine 30mL + epi 200K times 2 (bilateral)
GeneralNot detailed IV morphine eq only Ibuprofen
Acetaminophen
Text
Table

Hutchins et. al [18]2016Laparoscopic Hand-assisted nephrectomy30/29Exparel 10 mL
(266mg) + 20mL NS
0.25% Bupivacaine 30mL (bilateral)
GeneralIV hydromorphone
Fentanyl
Hydromorphone PO
Hydrocodone PO
Oxycodone PO
Text
Table

Knight et. al [19]2015Laparoscopic Urologic Surgery97/94Exparel 20 mL
(266mg) + 40mL NS
0.25% Bupivacaine 60mL
GeneralHydrocodone/Acetaminophen
IV morphine
Text
Figure

Knudson et. al [20]2016Colon Resection27/30Exparel 20 mL
(266mg) + 10mL NS
Bupivacaine 0.5% 30mL
GeneralHydromorphone-Patient Controlled analgesia pump
5mg/325mg hydrocodone/acetaminophen as needed
Text
Table
Figure

Schroer et. al [21]2015Total Knee Arthroplasty58/53Exparel 20 mL (266mg)
+ 30mL 0.25% Bupivacaine
0.25% Bupivacaine 60mL
SpinalCelecoxib 400mg daily
Oxycontin 10mg q 12h
IV-PCA morphine
Text
Table