Effects of a Single Dose of Parecoxib on Inflammatory Response and Ischemic Tubular Injury Caused by Hemorrhagic Shock in Rats

Table 1

Serum cytokine levels in each of the four groups of rats.

Parameter	Plc/NH ()	Pcx/NH ()	Plc/H ()	Pcx/H ()
IL-1α	36.8 ± 12.3	27.9 ± 16.1	60.2 ± 40.6	37.0 ± 17.9
IL-1β	41.5 ± 19.0	50.5 ± 41.1	66.0 ± 21.0	48.6 ± 23.4
IL-6	142.9 ± 69.3	205.1 ± 193.3	449.2 ± 160.8	229.3 ± 241.9
IL-10	123.5 ± 103.2	58.0 ± 30.7	365.3 ± 322.1	182.6 ± 99.9
TNF-α	21.2 ± 7.7	20.4 ± 18.6	42.4 ± 23.2	27.1 ± 12.6

Data were expressed as picogram per mL of serum; values are means ± SD; is number of animals. Plc/NH = placebo/no hemorrhage group, Pcx/NH = parecoxib/no hemorrhage group, Plc/H = Placebo/hemorrhage group, and Pcx/H = parecoxib/hemorrhage group; Plc/H > Plc/NH, Pcx/NH, and Pcx/H, .