Review Article

Therapeutic Options of Chondrodermatitis Nodularis Helicis

Table 1

Topical treatment.

First author and yearNumber of patientsMethodCure rateFollow-up
(mean)
Recurrence ratePros and cons

Pressure relieving padding
Travelute 2013 [25]10Self-adhering foam90%Not reported0Retrospective. Follow-up not reported.
Naqash   2013 [59]1 Ear-paddingPain resolved6 weeks0Case report. Short follow-up.
Kuen-Spiegl 2011 [9] 12 (18) Bandage + foam plastic92%41–61 months25% (but discontinued treatment) Prospective. 6 did not comply.
Durrant 2011 [12] 75Customized ear prosthesis74%52 months31%Prospective. Confounder with topical steroid.
Sanu 2007 [13] 23Doughnut pillow57%12 months0Prospective. 7 did not comply.
Moncrieff 2004 [26]15Foam-padding strapped to head87%18 weeks0Retrospective. Short follow-up.
Timoney 2002 [14]12Different decompression methods92%24 months8%Prospective. Used several methods.

Topical nitroglycerin
Sanz-Motilva 2015 [27]290,2% topical nitroglycerin93%5,9 months0,03%Retrospective. Confounder with decompression.
Colmenero  2014 [15]11Transdermal nitroglycerin patch64%3 months0Prospective. Lack of histology.
Yélamos 2013 [48]12% nitroglycerin gelGood effect4 months0Case report.
Flynn  2011 [28]12 pt/13 lesions2% topical nitroglycerin92%2–13 months0 (within follow-up period)Retrospective. Wide range of follow-up.

Glucocorticoid injection
Cox 2002 [29]601x triamcinolone intralesionally40% 3 months/33% long-term3–96 months6%Retrospective.
Lawrence 1991 [8]44Triamcinolone, 0,2–0,5 mL intralesionally + topical betamethasone 2 daily + lidocaine gel 2% before bed for 8 weeks27% at 8 weeks 16 months (4,5–34)Non-respondents went on to surgery. Respondents had 0 recurrence after 14 monthsProspective. Confounding therapies.
Schmidt  1984 [36]3Local infiltration with Prednisolon-crystal-suspension, 3–6 inj.67%1 week after last treatmentNot reportedCase series. No follow-up after last treatment.
Wade 1979 [16]8Intralesional inj. with triamcinolone100%0–12 months0Prospective. Unsure follow-up.

Injectable collagen
Greenbaum 1991 [17]5Collagen inj. over perichondrium100%16 months0 Prospective.