Table of Contents
Magnetic Separation News
Volume 1, Issue 2, Pages 103-109

The Use of Magnetic Microspheres for the Removal of Tumour Cells From Bone Marrow

1ICRF Laboratory, Institute of Child Health, 30 Guilford Street, London, UK
2Institute of Industrial Chemistry, The Norwegian Institute of Technology, The University of Trondheim, Trondheim N7034, Norway
3Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California, USA

Received 28 August 1983

Copyright © 1984 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A technique for the removal of tumour cells from bone marrow is described. This involves rendering the tumour cells ‘magnetic’ by attaching them to magnetite–containing microspheres by a double layer of antibody. Bone marrow conraining these ‘magnetic’ tumour cells is then passed through a system of magnets so that the tumour cells are drawn out of the bone marrow. Treated bone marrow may then be reinfused into the patient from which it was taken.