The Use of Magnetic Microspheres for the Removal of Tumour
Cells From Bone Marrow
Jennifer G. Treleaven,1Frances M. Gibson,1John Ugelstad,2Alan Rembau,3and John T. Keshead1
Received28 Aug 1983
Abstract
A technique for the removal of tumour cells from
bone marrow is described. This involves rendering the tumour
cells ‘magnetic’ by attaching them to magnetite–containing
microspheres by a double layer of antibody. Bone marrow conraining
these ‘magnetic’ tumour cells is then passed through
a system of magnets so that the tumour cells are drawn out of
the bone marrow. Treated bone marrow may then be reinfused
into the patient from which it was taken.