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Sarcoma
Volume 6 (2002), Issue 4, Pages 135-139
http://dx.doi.org/10.1080/1357714021000066386
Case Report

A Sarcoma at the Site of Previous Extravasation of Adriamycin

1Department of Surgical Oncology, University Hospital Catholic University Leuven, Herestraat 49, Leuven B-3000, Belgium
2Department of Pathology, University Hospital Catholic University Leuven, Herestraat, Leuven B-3000, Belgium
3Centre for Human Genetics, University Hospital Catholic University Leuven, Herestraat, Leuven B-3000, Belgium
4Department of Oncology, University Hospital Catholic University Leuven, Herestraat, Leuven B-3000, Belgium

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We report the case of a 66-year-old man presenting with a high-grade pleomorphic sarcoma at the left elbow 16 years after the extravasation of adriamycin given for a malignant ifbrous histiocytoma of the tibia.We suggest that this sarcoma originated in a multistep way over many years, out of the chronic inflammatory tissue that developed due to a non-specific cellular damage at the nuclear level, interfering with normal cell replication necessary for normal healing tissue healing. As a result, the non-healed chronic inflammatory tissue transformed over several years into a preneoplastic mesenchymal tumour and later into a high-grade pleomorphic sarcoma.