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Volume 7, Issue 2, Pages 81-85
Case Report

Metastatic Secondary Fibrosarcoma of Bone Responsive to Repeated Courses of Ifosfamide and Associated With Hypoglycemia

1Department of Medical Oncology, London Regional Cancer Centre, 399 Royal Avenue, Kelowna, BC, London V1Y 5L3, Canada
2Division of Endocrinology, Department of Medicine, St. Joseph's Hospital, Ontario, London, Canada

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We present a case of a 40-year-old man with secondary fibrosarcoma of bone, arising from a non-ossifying fibroma. He subsequently developed metastatic disease that responded to four successive chemotherapy courses, the last three using the same dose/schedule of single agent ifosfamide. Eventual rapid progression of a huge intra-abdominal mass was associated with the syndrome of extrapancreatic tumour hypoglycemia (EPTH). The clinicopathological behaviour of fibrosarcoma of bone, and the mechanism of EPTH are discussed.