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Volume 8 (2004), Issue 1, Pages 47-49
Case Report

Osteosarcoma Associated With Diamond-Blackfan Anaemia: A Case of a Child Receiving Growth Hormone Therapy

Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore, Middx HA7 4LP, UK

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose: Diamond–Blackfan anaemia (DBA) is a rare pure congenital red cell aplasia, usually presenting in infancy or early childhood. The literature suggests a predisposition to haemopoietic malignancy but in addition solid tumours have been reported, with five cases of osteosarcoma described.

Patient: A sixth case of a 12-year-old girl with DBA who developed an osteosarcoma of the distal femur is presented.

Results: She was treated with methotrexate followed by tumour excision and distal femoral replacement. The patient is currently alive with multiple pulmonary metastases.

Discussion: We discuss the association between the administration of growth hormone and future development of malignancy in patients with DBA.