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Volume 2008, Article ID 416085, 3 pages
Case Report

Coexistence of Two Rare Sarcomas: Primary Leiomyosarcoma of Bone and Epithelioid Hemangioendothelioma of the Liver

1The Division of Medical Oncology, “12 de Octubre” University Hospital, Madrid 28041, Spain
2The Division of Pathology, “12 de Octubre” University Hospital, Madrid 28041, Spain
3The Division of Radiology, Hospital Clínico de Madrid, Madrid 28040, Spain

Received 4 October 2007; Accepted 24 January 2008

Academic Editor: Raphael E. Pollock

Copyright © 2008 E. Gonzalez-Billalabeitia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 33-year-old woman sought medical attention for a painful swelling of the left ankle. Plain radiographs revealed an osteolytic lesion involving the left distal tibia. An excisional biopsy provided the diagnosis of leiomyosarcoma in the tibia. A staging work-up was performed and an abdominal CT showed 4 liver hypodense lesions in both lobes with peripheral contrast enhancement. A liver biopsy confirmed the diagnosis of epithelioid hemangioendothelioma of the liver. No association between these two entities has been described before. This case introduces the importance of the pathological confirmation of apparent metastatic lesions in low grade sarcomas and provides a review of the literature of both tumours.