Immunohistochemical Estimates of Angiogenesis, Proliferative Activity, p53 Expression, and Multiple Drug Resistance Have No Prognostic Impact in Osteosarcoma: A Comparative Clinicopathological Investigation

Table 3

Angiogenesis, tumor cell proliferation, and nuclear p53 expression in primary, diagnostic biopsies from osteosarcomas.

	N	Mean	SD	Range
Angiogenesis^a	95	6.79	2.50	2.00–14.00
Proliferation rate (%)	117	50.6	18.8	5.1–90.2
Proliferation index (mm^−2)	117	1990	1164	14–8388
p53 expression (%)	117	68.0	24.4	5.5–100.0
p53 index (mm^−2)	117	2615	1437	15–10556

^aIt was technically impossible to obtain evaluable immunohistochemical stains for CD34 in 12 cases.