Immunohistochemical Estimates of Angiogenesis, Proliferative Activity, p53 Expression, and Multiple Drug Resistance Have No Prognostic Impact in Osteosarcoma: A Comparative Clinicopathological Investigation

Table 4

The relationships between estimates of tumor cell proliferation and nuclear p53 expression in 46 osteosarcomas, before and after preoperative chemotherapy.

	Pre-chemotherapy		Post-chemotherapy
	N	Mean	N	Mean	𝑃value^a
Proliferation rate (%)	46	54.48	39^b	42.8	.86
Proliferation index (mm^−2)^c	46	2230	39^b	1327	.𝟎𝟐
p53 expression (%)	46	61.0	39^b	64.8	.85
p53 index (mm^−2)^c	46	2573	39^b	2190	.32

^aStudent’s unpaired t-test.
^bOne case could not be evaluated, whereas 6 cases were associated with 100% tumor necrosis.
^cIndex reflects the number of positive nuclear profiles pr. mm² tissue.