Malignant Progression in Two Children with Multiple Osteochondromas
(a) Low-power micrograph (10×) of the low-grade chondrosarcoma: H&E stained normal cartilage (left) is separated by a fibrous band from an expansile nodule of malignant cartilage (right). (b) 40× photomicrograph reveals a region of typical benign cartilage of an osteochondroma, with cells of similar sizes organized in rows. (c) 40× photomicrograph of malignant cartilage demonstrating both the crowded conditions and the irregular configuration of the large nuclei in the malignant component.
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