Table of Contents Author Guidelines Submit a Manuscript
Sarcoma
Volume 2010, Article ID 454792, 7 pages
http://dx.doi.org/10.1155/2010/454792
Research Article

Clinical Features of Sarcomatoid Carcinoma (Carcinosarcoma) of the Urinary Bladder: Analysis of 221 Cases

1Section of Oncology-Hematology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-7680, USA
2Department of Internal Medicine, Creighton University School of Medicine, Omaha, NE 68131, USA
3Urologic Surgery Section, Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-2360, USA

Received 15 March 2010; Accepted 27 May 2010

Academic Editor: Alberto Pappo

Copyright © 2010 Jue Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. R. Wick and P. E. Swanson, “Carcinosarcomas: current perspectives and an historical review of nosological concepts,” Seminars in Diagnostic Pathology, vol. 10, no. 2, pp. 118–127, 1993. View at Google Scholar · View at Scopus
  2. F. Holtz, J. E. Fox, and M. R. Abell, “Carcinosarcoma of the urinary bladder,” Cancer, vol. 29, no. 2, pp. 294–304, 1972. View at Google Scholar · View at Scopus
  3. R. H. Young, “Carcinosarcoma of the urinary bladder,” Cancer, vol. 59, no. 7, pp. 1333–1339, 1987. View at Google Scholar · View at Scopus
  4. A. Giannopoulos, G. Alivizatos, V. Kyriakou, D. Mitropoulos, and M. A. Dimopoulos, “Carcinosarcoma of the bladder,” British Journal of Urology, vol. 67, no. 1, pp. 106–107, 1991. View at Google Scholar · View at Scopus
  5. S. H. Sigal, J. E. Tomaszewski, J. J. Brooks, A. Wein, and V. A. LiVolsi, “Carcinosarcoma of bladder following long-term cyclophosphamide therapy,” Archives of Pathology and Laboratory Medicine, vol. 115, no. 10, pp. 1049–1051, 1991. View at Google Scholar · View at Scopus
  6. S. Mukhopadhyay, A. E. Shrimpton, L. A. Jones, I. S. Nsouli, and N. Z. Abraham Jr., “Carcinosarcoma of the urinary bladder following cyclophosphamide therapy: evidence for monoclonal origin and chromosome 9p allelic loss,” Archives of Pathology and Laboratory Medicine, vol. 128, pp. e8–e11, 2004. View at Google Scholar
  7. C. A. Bloxham, M. K. Bennett, and M. C. Robinson, “Bladder carcinosarcomas: three cases with diverse histogenesis,” Histopathology, vol. 16, no. 1, pp. 63–67, 1990. View at Google Scholar · View at Scopus
  8. C. Lahoti, R. Schinella, A. F. Rangwala, M. Lee, and H. Mizrachi, “Carcinosarcoma of urinary bladder: report of 5 cases with immunohistologic study,” Urology, vol. 43, no. 3, pp. 389–393, 1994. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Lopez-Beltran, A. Pacelli, H. J. Rothenberg, P. C. Wollan, H. Zincke, M. L. Blute, and D. G. Bostwick, “Carcinosarcoma and sarcomatoid carcinoma of the bladder: clinicopathological study of 41 cases,” Journal of Urology, vol. 159, no. 5, pp. 1497–1503, 1998. View at Google Scholar · View at Scopus
  10. L. Perret, P. Chaubert, D. Hessler, and L. Guillou, “Primary heterologous carcinosarcoma (metaplastic carcinoma) of the urinary bladder: a clinicopathologic, immunohistochemical, and ultrastructural analysis of eight cases and a review of the literature,” Cancer, vol. 82, no. 8, pp. 1535–1549, 1998. View at Google Scholar · View at Scopus
  11. H.-U. Völker, A. Zettl, and A. Zettl, “Molecular genetic findings in two cases of sarcomatoid carcinoma of the ureter: evidence for evolution from a common pluripotent progenitor cell?” Virchows Archiv, vol. 452, no. 4, pp. 457–463, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. S. Halachmi, A. M. DeMarzo, and A. M. DeMarzo, “Genetic alterations in urinary bladder carcinosarcoma: evidence of a common clonal origin,” European Urology, vol. 37, no. 3, pp. 350–357, 2000. View at Google Scholar · View at Scopus
  13. A. B. Armstrong, M. Wang, and M. Wang, “TP53 mutational analysis supports monoclonal origin of biphasic sarcomatoid urothelial carcinoma (carcinosarcoma) of the urinary bladder,” Modern Pathology, vol. 22, no. 1, pp. 113–118, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. M. R. Wick, B. A. Brown, R. H. Young, and S. E. Mills, “Spindle-cell proliferations of the urinary tract: an immunohistochemical study,” American Journal of Surgical Pathology, vol. 12, no. 5, pp. 379–389, 1988. View at Google Scholar · View at Scopus
  15. F. Gorstein and T. L. Anderson, “Malignant mixed mesodermal tumors: carcinoma, sarcoma, or both?” Human Pathology, vol. 22, no. 3, pp. 207–209, 1991. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Thompson, B. Chang, and S. H. Barsky, “Monoclonal origins of malignant mixed tumors (carcinosarcomas): evidence for a divergent histogenesis,” American Journal of Surgical Pathology, vol. 20, no. 3, pp. 277–285, 1996. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Torenbeek, C. E. M. Blomjous, P. C. De Bruin, D. W. W. Newling, and C. J. L. M. Meijer, “Sarcomatoid carcinoma of the urinary bladder: clinicopathologic analysis of 18 cases with immunohistochemical and electron microscopic findings,” American Journal of Surgical Pathology, vol. 18, no. 3, pp. 241–249, 1994. View at Google Scholar · View at Scopus
  18. Surveillance, Epidemiology, and End Results (SEER) Program, “Public-Use Data (1973–2004),” National Cancer Institute, DCCPS, Surveillance Research Program, Cancer Statistics Branch, released April 2002, based on the November 2006 submission, November 2008, http://www.seer.cancer.gov/about/expansion.html.
  19. E. L. Kaplan and P. Meier, “Nonparametric estimation from incomplete observations,” Journal of the American Statistical Association, vol. 53, pp. 457–481, 1958. View at Google Scholar
  20. D. R. Cox, “Regression models and life-tables,” Journal of the Royal Statistical Society B, vol. 34, pp. 187–220, 1972. View at Google Scholar
  21. Y. S. Gürbüz, B. Müezzinoglu, K. Çimen, and Ö. Dillioglugil, “Synchronous occurrence of bladder carcinosarcoma and testicular seminoma,” International Journal of Urology, vol. 8, no. 7, pp. 404–407, 2001. View at Publisher · View at Google Scholar · View at Scopus
  22. L. P. Nedergaard and G. K. Jacobsen, “Simultaneous occurrence of carcinosarcoma of the bladder and seminoma of the testis. Case report,” Scandinavian Journal of Urology and Nephrology, vol. 27, no. 3, pp. 429–430, 1993. View at Google Scholar · View at Scopus
  23. G. Orsatti, F. J. Corgan, and S. A. Goldberg, “Carcinosarcoma of urothelial organs: sequential involvement of urinary bladder, ureter, and renal pelvis,” Urology, vol. 41, no. 3, pp. 289–291, 1993. View at Publisher · View at Google Scholar · View at Scopus
  24. J. L. Wright, P. C. Black, G. A. Brown, M. P. Porter, A. M. Kamat, C. P. Dinney, and D. W. Lin, “Differences in survival among patients with sarcomatoid carcinoma, carcinosarcoma and urothelial carcinoma of the bladder,” Journal of Urology, vol. 178, no. 6, pp. 2302–2306, 2007. View at Google Scholar
  25. J. P. Stein, G. Lieskovsky, and G. Lieskovsky, “Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients,” Journal of Clinical Oncology, vol. 19, no. 3, pp. 666–675, 2001. View at Google Scholar · View at Scopus
  26. C. G. Rogers, G. S. Palapattu, and G. S. Palapattu, “Clinical outcomes following radical cystectomy for primary nontransitional cell carcinoma of the bladder compared to transitional cell carcinoma of the bladder,” Journal of Urology, vol. 175, no. 6, pp. 2048–2053, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  27. J. B. Wallach, B. Wang, and N. Sanfilippo, “High-grade hyperinvasive sarcomatoid urothelial bladder carcinoma demonstrating complete response to bladder-preserving chemoradiation,” Current Oncology, vol. 16, no. 3, pp. 55–57, 2009. View at Google Scholar · View at Scopus
  28. S. Hoshi, M. Sasaki, and M. Sasaki, “Case of carcinosarcoma of urinary bladder obtained a pathologically complete response by neoadjuvant chemoradiotherapy,” International Journal of Urology, vol. 14, no. 1, pp. 79–81, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. R. Damiano, M. D'Armiento, F. Cantiello, A. Amorosi, P. Tagliaferri, R. Sacco, and S. Venuta, “Gemcitabine and cisplatin following surgical treatment of urinary bladder carcinosarcoma,” Tumori, vol. 90, no. 5, pp. 458–460, 2004. View at Google Scholar
  30. A. Bicher, C. Levenback, E. G. Silva, T. W. Burke, M. Morris, and D. M. Gershenson, “Ovarian malignant mixed mullerian tumors treated with platinum-based chemotherapy,” Obstetrics and Gynecology, vol. 85, no. 5 I, pp. 735–739, 1995. View at Publisher · View at Google Scholar · View at Scopus
  31. H. von der Maase, S. W. Hansen, J. T. Roberts et al., “Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study,” Journal of Clinical Oncology, vol. 18, no. 17, pp. 3068–3077, 2000. View at Google Scholar · View at Scopus
  32. M. Froehner, H. J. Gaertner, A. Manseck, and M. P. Wirth, “Durable complete remission of metastatic sarcomatoid carcinoma of the bladder with cisplatin and gemcitabine in an 80-year-old man,” Urology, vol. 58, no. 5, p. 799, 2001. View at Google Scholar