Case Report

Scalp Angiosarcoma Remission with Bevacizumab and Radiotherapy without Surgery: A Case Report and Review of the Literature

Table 1

Different treatments used in cutaneous angiosarcoma.

ReferenceType of literatureAngiosarcoma typeTreatmentOutcome

Koontz et al. 2008 [16] Case reports(1) Nasal area(1) Bevacizumab + XRT + SX(1) CR, 26 mos response duration
(2) Nasal area(2) Bevacizumab + XRT + SX(2) CR, 8.5 mos response duration

Gkalpakiotis et al. 2008 [17]Case reportWell-differentiated exophytic-faceXRT alone
Phase 1: 45 Gy
Phase 2: 20 Gy
5 yrs remission

Schlemmer et al. 2008 [18] Retrospective study32 patientsPaclitaxel5/8 PR (mean 5.8 mos)
8 scalp and facial± Sx1/8 CR (42 mos)
Rest other sites± XRT1/8 PD (3 mos)
± chemotherapy1/8 NC (2 mos)

Nagano et al. 2007 [19] Retrospective study 9 patients Cutaneous ASDocetaxel with or without other previous treatment (XRT, SX) 6/9: major response (2 CR, 4 PR)
2CR: 2 XRT without SX
4 PR: 1 XRT + SX, 1 XRT without SX, 1 SX without XRT, 1 without SX nor XRT

Holloway et al. 2005 [20]Case reportCutaneous AS (scalp)Liposomal doxorubicin + XRT4 years response duration

Eiling et al. 2002 [21] Case reportCutaneous AS (scalp)Liposomal doxorubicin + XRTCR with cervical lymph node metastasis disappearance
4 mos response duration

Lankester et al. 1999 [22]Case reportCutaneous AS (face and scalp)Liposomal daunorubicin + XRT15 mos CR

CR: complete response, PR: partial response, NC: no change, PD: progression of disease, XRT: radiotherapy, SX: surgery.