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Sarcoma
Volume 2011 (2011), Article ID 185465, 6 pages
http://dx.doi.org/10.1155/2011/185465
Case Report

High Efficacy of Preoperative Low-Dose Radiotherapy with Sanazole (AK-2123) for Extraskeletal Ewing's Sarcoma: A Case Report

1Department of Orthopedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
2Division of Surgical Pathology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
3Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
4Health Research Foundation, Kinki Invention Center, 14 Yoshida-Kawaramachi, Sakyo-ku, Kyoto 606-8255, Japan

Received 29 June 2010; Accepted 20 August 2010

Academic Editor: Ajay Puri

Copyright © 2011 Tomoya Sakabe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. S. Lee, Y. H. Kim, H. K. Chee et al., “Multimodal treatment of primary extraskeletal Ewing's sarcoma of the chest wall: report of 2 cases,” Cancer Research and Treatment, vol. 41, no. 2, pp. 108–112, 2009. View at Google Scholar
  2. S.-H. Ng, S.-F. Ko, Y.-C. Cheung, H.-F. Wong, and S.-M. Jung, “Extraskeletal Ewing's sarcoma of the parapharyngeal space,” British Journal of Radiology, vol. 77, no. 924, pp. 1046–1049, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Laskar, I. Mallick, T. Gupta, and M. A. Muckaden, “Post-operative radiotherapy for Ewing sarcoma: when, how and how much?” Pediatric Blood and Cancer, vol. 51, no. 5, pp. 575–580, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  4. J. Dunst, R. Sauer, J. M. V. Burgers et al., “Radiation therapy as local treatment in Ewing's sarcoma: results of the cooperative Ewing's sarcoma studies CESS 81 and CESS 86,” Cancer, vol. 67, no. 11, pp. 2818–2825, 1991. View at Google Scholar · View at Scopus
  5. R. Ahmad, B. R. Mayol, M. Davis, and B. T. Rougraff, “Extraskeletal Ewing's sarcoma,” Cancer, vol. 85, no. 3, pp. 725–731, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. L. J. Sheplan and J. J. Juliano, “Use of radiation therapy for patients with soft-tissue and bone sarcomas,” Cleveland Clinic Journal of Medicine, vol. 77, supplement 1, pp. S27–S29, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  7. W. Dobrowsky, N. G. Huigol, R. S. Jayatilake et al., “AK-2123 (Sanazol) as a radiation sensitizer in the treatment of stage III cervical cancer: results of an IAEA multicentre randomised trial,” Radiotherapy and Oncology, vol. 82, no. 1, pp. 24–29, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. N. G. Huilgol, N. Chatterjee, and A. R. Mehta, “An overview of the initial experience with AK-2123 as a hypoxic cell sensitizer with radiation in the treatment of advanced head and neck cancers,” International Journal of Radiation Oncology Biology Physics, vol. 34, no. 5, pp. 1121–1124, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. S. D. Ullal, K. K. Shenoy, M. R. S. M. Pai et al., “Safety and radiosensitizing efficacy of sanazole (AK 2123) in oropharyngeal cancers: randomized controlled double blind clinical trial,” Indian Journal of Cancer, vol. 43, no. 4, pp. 151–155, 2006. View at Google Scholar · View at Scopus
  10. T. V. Kagiya, “International coordinated research program of nitrotriazole sensitization of cancer therapy,” Japanese Journal of Clinical Oncology, vol. 55, no. 4, pp. 245–254, 2009. View at Google Scholar
  11. J. G. Kennedy, S. Eustace, R. Caulfield, D. J. Fennelly, B. Hurson, and K. S. O'Rourke, “Extraskeletal Ewing's sarcoma: a case report and review of the literature,” Spine, vol. 25, no. 15, pp. 1996–1999, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. C. C. Cheung, R. A. Kandel, R. S. Bell, R. E. Mathews, and D. M. D. Ghazarian, “Extraskeletal Ewing sarcoma in a 77-year-old woman,” Archives of Pathology and Laboratory Medicine, vol. 125, no. 10, pp. 1358–1360, 2001. View at Google Scholar · View at Scopus
  13. T. J. Kinsella, T. J. Triche, P. S. Dickman, J. Costa, J. E. Tepper, and D. Glaubiger, “Extraskeletal Ewing's sarcoma: results of combined modality treatment,” Journal of Clinical Oncology, vol. 1, no. 8, pp. 489–495, 1983. View at Google Scholar · View at Scopus
  14. R. B. Raney, L. Asmar, W. A. Newton Jr. et al., “Ewing's sarcoma of soft tissues in childhood: a report from the Intergroup Rhabdomyosarcoma Study, 1972 to 1991,” Journal of Clinical Oncology, vol. 15, no. 2, pp. 574–582, 1997. View at Google Scholar · View at Scopus
  15. K. I. Desai, T. D. Nadkarni, A. Goel, D. P. Muzumdar, K. N. Naresh, and C. N. Nair, “Primary Ewing's sarcoma of the cranium,” Neurosurgery, vol. 46, no. 1, pp. 62–69, 2000. View at Google Scholar · View at Scopus
  16. G. Rosen, B. Caparros, A. Nirenberg et al., “Ewing's sarcoma: ten-year experience with adjuvant chemotherapy,” Cancer, vol. 47, no. 9, pp. 2204–2213, 1981. View at Google Scholar · View at Scopus
  17. M. Bernstein, H. Kovar, M. Paulussen et al., “Ewing's sarcoma family of tumors: current management,” Oncologist, vol. 11, no. 5, pp. 503–519, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. D.-Y. Yu, Q.-L. Zhao, Z.-L. Wei et al., “Enhancement of radiation-induced apoptosis of human lymphoma U937 cells by sanazole,” Apoptosis, vol. 14, no. 5, pp. 655–664, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. M. Lahl, V. L. Fisher, and K. Laschinger, “Ewing's sarcoma family of tumors: an overview from diagnosis to survivorship,” Clinical Journal of Oncology Nursing, vol. 12, no. 1, pp. 89–97, 2008. View at Google Scholar · View at Scopus
  20. T. E. Merchant, B. H. Kushner, J. M. Sheldon, M. LaQuaglia, and J. H. Healey, “Effect of low-dose radiation therapy when combined with surgical resection for Ewing sarcoma,” Medical and Pediatric Oncology, vol. 33, no. 2, pp. 65–70, 1999. View at Publisher · View at Google Scholar · View at Scopus
  21. R. Sauer, H. Jurgens, J. M. V. Burgers, J. Dunst, R. Hawlicek, and J. Michaelis, “Prognostic factors in the treatment of Ewing's sarcoma. The Ewing's Sarcoma Study Group of the German Society of Paediatric Oncology CESS 81,” Radiotherapy and Oncology, vol. 10, no. 2, pp. 101–110, 1987. View at Google Scholar · View at Scopus