Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma
Figure 1
Cooperative mutations in the development of Ewing’s sarcoma. (a) A t(11;22) reciprocal translocation produces the EWS-FLI1 gene, but this tends to cause growth arrest in normal cells. (b) A mutation randomly occurring prior to the t(11;22) translocation might cooperate with EWS-FLI1 to permit escape from growth arrest (or even promote cell proliferation) and subsequent transformation to Ewing’s sarcoma. (c) The cooperative mutation may occur after the t(11;22) translocation; this would necessarily imply a mechanism for continued cell growth after EWS-FLI1 is expressed.
