Axial Skeletal Location Predicts Poor Outcome in Ewing's Sarcoma: A Single Institution Experience

Table 3

Effect of anatomic location in univariable (model 1), multivariable analysis when adjusting for pre-treatment variables (model 2), and when adjusting for pre-treatment and treatment variables (model 3).

Variable/model	Model 1		Model 2		Model 3
	HR [95% CI]	𝑃 value	HR [95% CI]	𝑃 value	HR [95% CI]	𝑃 value
Site (axial)	3.07 [1.44–6.52]	0.0022	3.11 [1.41–6.84]	0.0048	4.73 [0.87–25.74]	0.072
Size (large)	—	—	3.85 [1.44–10.32]	0.0072	4.35 [0.78–24.34]	0.094
Metastasis (yes)	—	—	2.9 [1.37–6.13]	0.0055	2.99 [0.31–5.01]	0.34
Radiation (yes)	—	—	—	—	0.79 [0.13–5.01]	0.81
Surgical margins (positive)	—	—	—	—	2.47 [0.63–9.63]	0.19

HR (hazard ratio); 95% CI (95% confidence interval).