Targeting the Insulin-Like Growth Factor 1 Receptor in Ewing's Sarcoma: Reality and Expectations
Figure 2
Confirmed responses to figitumumab in Ewing’s sarcoma. (a) This figure illustrates a response in a 12-year-old male patient with metastatic Ewing’s sarcoma treated with figitumumab 20 mg/kg every 4 weeks. The baseline, 6 and 32 cycle CT scans show a complete response (confirmed pathologically) in the target hilar mass and other subcentimeter lung nodules. (b) This figure illustrates a response in a 24-year-old male patient with metastatic extraskeletal Ewing’s sarcoma treated with figitumumab 20 mg/kg every 4 weeks. The baseline and cycle 4 CT scan demonstrate complete eradication of several <2 cm lung metastases and a significant reduction in the mediastinal mass. The response to figitumumab was consolidated with 45 Gy in 15 fractions. The patient has an ongoing partial response after 25 cycles. (Adapted from [67]).
