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Sarcoma
Volume 2011 (2011), Article ID 405437, 15 pages
http://dx.doi.org/10.1155/2011/405437
Review Article

Chondrosarcoma: With Updates on Molecular Genetics

1Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea
2Department of Pathology, Weill Medical College of Cornell University, The Methodist Hospital, Houston, TX 77030, USA

Received 14 September 2010; Revised 23 November 2010; Accepted 17 December 2010

Academic Editor: C. Verhoef

Copyright © 2011 Mi-Jung Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chondrosarcoma (CHS) is a malignant cartilage-forming tumor and usually occurs within the medullary canal of long bones and pelvic bones. Based on the morphologic feature alone, a correct diangosis of CHS may be difficult, Therefore, correlation of radiological and clinicopathological features is mandatory in the diagnosis of CHS. The prognosis of CHS is closely related to histologic grading, however, histologic grading may be subjective with high inter-observer variability. In this paper, we present histologic grading system and clinicopathological and radiological findings of conventional CHS. Subtypes of CHSs, such as dedifferentiated, mesenchymal, and clear cell CHSs are also presented. In addition, we introduce updated cytogenetic and molecular genetic findings to expand our understanding of CHS biology. New markers of cell differentiation, proliferation, and cell signaling might offer important therapeutic and prognostic information in near future.