Immune-Based Therapies for Sarcoma

Table 1

Selected CT antigen expression (all with A*02.01 epitopes) in selected sarcomas.

Sarcoma subtype	Reference	Method	NY-ESO-1	LAGE-1	PRAME	MAGE-A3	MAGE-A4	MAGE-A9	SSX-2
MFH/pleomorphic spindle cell	[32]	RT-PCR	1/6	0/6		1/6	0/6
	[33]	RT-PCR							1/2
	[31]	Microarray		0/16	1/16			1/16
Liposarcoma	[32]	RT-PCR	2/2	1/2		1/2	2/2
	[33]	RT-PCR							1/2
Myxoid	[31]	Microarray		5/7	6/7			5/7
Nonmyxoid	[31]	Microarray		3/5	5/5			2/5
Leiomyosarcoma	[31]	Microarray		0/9	3/9			1/9
Uterine leiomyosarcoma	[32]	RT-PCR	3/5	2/5		3/5	4/5
	[33]	RT-PCR							3/4
Nonuterine leiomyosarcoma	[32]	RT-PCR	0/7	1/7		1/7	2/7
	[32]	RT-PCR							0/1
Synovial sarcoma	[32]	RT-PCR	2/2	1/2		1/2	2/2
	[30]	IHC	20/25
	[31]	Microarray		3/4	4/4			3/4
Skeletal sarcomas
Osteosarcoma	[32]	RT-PCR	0/1	0/1		0/1	0/1
	[33]	RT-PCR							0/1
	[34]	qRT-PCR	8/9 (NY-ESO + LAGE)			9/9	4/9
Ewings Sarcoma	[34]	qRT-PCR	0/18 (NY-ESO + LAGE)			5/18	4/18
Chondrosarcoma	[32]	RT-PCR	2/2	2/2		2/2	1/2