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Sarcoma
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Sarcoma
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2011
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Article
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Fig 2
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Review Article
Liposarcoma: Molecular Genetics and Therapeutics
Figure 2
Cyclin dependent kinase CDK4 binds with cyclin D to form active complexes. This results in phosphorylation of Rb and dissociates pRb from the pRb-E2F complex. E2F binds DNA to upregulate transcription of genes required to progress to S phase.