Cell Cycle Deregulation in Ewing's Sarcoma Pathogenesis

Figure 1

Overview of the cell cycle. Progression through the cell cycle is mediated by cyclin-CDK complexes that regulate RB function. Cyclin-dependent kinase inhibitors negatively regulate this process in order to control DNA replication and cell division. Based on the data presented above, regulators of the cell cycle thought to be involved in Ewing’s sarcoma pathogenesis are indicated. (Note: in an effort to be concise, only the most significant regulators and their respective functions are included in the diagram).