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Volume 2011, Article ID 736841, 8 pages
Review Article

Ewing's Sarcoma and Second Malignancies

1Division of Pediatric Hematology/Oncology, University of Utah School of Medicine, Salt Lake City, UT 84113, USA
2Center for Children's Cancer Research, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA

Received 30 June 2010; Accepted 30 August 2010

Academic Editor: Ajay Puri

Copyright © 2011 Joshua D. Schiffman and Jennifer Wright. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ewing's sarcoma (ES) is a rare tumor that is most common in children and young adults. Late effects of ES therapy include second cancers, a tragic outcome for survivors of such a young age. This paper will explore the frequencies and types of malignancies that occur after ES. Additionally, it will review how second malignancies have changed with the shift in treatment from high-dose radiation to chemotherapy regimens including alkylators and epipodophyllotoxins. The risk of additional cancers in ES survivors will also be compared to survivors of other childhood cancers. Finally, the possible genetic contribution to ES and second malignancies will be discussed.