Review Article
Targeting the p53 Pathway in Ewing Sarcoma
Table 4
Involvement of the EWS gene in translocation-based malignancies.
| Tumour type | Fusion gene | Translocation | Reference |
| Ewing Sarcoma | EWS-FLI1 | t(11;22)(q24;q12) | [73] | EWS-ERG | t(21;22)(q22;q12) | [81] | EWS-ETV1 | t(7;22)(p22;q12) | [82] | EWS-ETV4 | t(17;22)(q12;q12) | [83] | EWS-FEV | t(2;22)(q33;q12) | [84] |
| Acute Leukemia | EWS-CIZ1 | t(12;22)(p13;q12) | [85] |
| Angiomatoid Fibrous | EWS-ATF1 | t(12;22)(q13;q12) | [86] | Histiocytoma | EWS-CREB1 | t(2;22)(q33;q12) | [87] |
| Clear-cell Sarcoma | EWS-ATF1 | t(12;22)(q13;q12) | [88] | EWS-CREB1 | t(2;22)(q33;q12) | [89] |
| Desmoplastic Small Round Cell Tumour | EWS-WT1 | t(11;22)(p13;q12) | [90] |
| Extraskeletal Myxoid | EWS-CHN1 | t(9;22)(q22–31;q11-12) | [91] | Chondrosarcoma | EWS-NR4A3 | t(9;22)(q22;q12) | [92] |
| Myxoid Liposarcoma | EWS-DDIT3 | t(12;22)(q13;q12) | [93] |
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