Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family

Table 2

FET gene fusions in cancer. TF: transcription factor.

Phenotype	FET partner	TF partner	TF type	Ref.
ESFT
(85%)	EWS	FLI1	ETS	[3]
(10%)	EWS	ERG	ETS	[82, 83]
(1%)	EWS	ETV1	ETS	[84]
(1%)	EWS	ETV4	ETS	[85, 86]
(1%)	EWS	FEV	ETS	[87]
(1%)	FUS	FEV	ETS	[25]
(1%)	FUS	ERG	ETS	[88]
ESFT-like	EWS	NFATC2	rel related	[89]
Askin-like, CD99 neg.	EWS	ZNF278	zinc finger	[90]
Bone sarcoma	EWS	POU5F1	pou	[91]
Mucoepidermoid carcinaoma	EWS	POU5F1	pou	[92]
Hidradenoma	EWS	POU5F1	pou	[92]
	EWS	PBX1	homeobox	[92]
Low-grade fibromyxoid sarcoma	FUS	CREB3L1	Leucine zipper	[93]
Myxoid liposarcoma	EWS	DDIT3	bZIP	[94]
	FUS	DDIT3	bZIP	[5]
Clear cell sarcoma	EWS	ATF1	bZIP	[95]
	EWS	CREB1	bZIP	[96]
Desmoplastic SRCT	EWS	WT1	zinc finger	[97]
Extraskeletal myxoid chondrosarcoma	EWS	NR4A3	nuclear receptor	[98]
	TAF15	NR4A3	nuclear receptor	[99]
AML	FUS	ERG	ETS	[100]
cALL, AUL	EWS	ZNF384	zinc finger	[101]
AML, ALL	TAF15	TAF15	zinc finger	[101]