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Sarcoma
Volume 2011, Article ID 932451, 8 pages
http://dx.doi.org/10.1155/2011/932451
Review Article

The Bone Niche of Chondrosarcoma: A Sanctuary for Drug Resistance, Tumour Growth and also a Source of New Therapeutic Targets

1INSERM, UMR 957, Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculté de Médecine, 1 rue Gaston Veil, 44035 Nantes Cedex 1, 44035 Nantes, France
2Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, 44035 Nantes, France
3University Hospital, Hôtel Dieu, CHU de Nantes, 44035 Nantes, France
4EA3855, University Hospital, 2 bd Tonnelle, 37044 Tours Cedex, France
5University Hospital, Hôpital Trousseau, CHRU de Tours, 37042 Tours Cedex, France

Received 25 November 2010; Revised 28 January 2011; Accepted 10 February 2011

Academic Editor: Ole Nielsen

Copyright © 2011 E. David et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chondrosarcomas are malignant cartilage-forming tumours representing around 20% of malignant primary tumours of bone and affect mainly adults in the third to sixth decade of life. Unfortunately, the molecular pathways controlling the genesis and the growth of chondrosarcoma cells are still not fully defined. It is well admitted that the invasion of bone by tumour cells affects the balance between early bone resorption and formation and induces an “inflammatory-like” environment which establishes a dialogue between tumour cells and their environment. The bone tumour microenvironment is then described as a sanctuary that contributes to the drug resistance patterns and may control at least in part the tumour growth. The concept of “niche” defined as a specialized microenvironment that can promote the emergence of tumour stem cells and provide all the required factors for their development recently emerges in the literature. The present paper aims to summarize the main evidence sustaining the existence of a specific bone niche in the pathogenesis of chondrosarcomas.