Review Article
Camptothecin-Based Regimens for Treatment of Ewing Sarcoma: sPast Studies and Future Directions
Table 1
Summary of selected studies using topotecan-based therapy for patients with relapsed/refractory Ewing sarcoma.
| | Author [Ref] | | Topotecan dose and schedule | Other drugs | Response Rate (complete + partial) | Comments |
| | Hawkins et al. [10] | 20 | 0.3 mg/m2/d for 21-day continuous infusion | — | 10% | | Blaney et al.
[9] | 3 | 1–1.3 mg/m2/d for 72-hour continuous infusion | — | 4% | | | Bernstein et al. [12] | 36 | 2 mg/m2/d × 5 | — | 8% | Given as upfront window for 6 weeks in newly diagnosed metastatic patients | | Bernstein et al. [12] | 37 | 0.75 mg/m2/d × 5 | CPM 250 mg/m2/d × 5 | 57%* | Given as upfront window for 6 weeks in newly diagnosed metastatic patients | | Saylors et al. [13] | 17 | 0.75 mg/m2/d × 5 | CPM 250 mg/m2/d × 5 | 35% | 50% of patients received at least 6 courses before progression | | Hunold et al. [14] | 49 | 0.75 mg/m2/d × 5 | CPM 250 mg/m2/d × 5 | 33% | Additional 26% with stable disease |
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*In newly diagnosed patients with metastatic disease; CPM, cyclophosphamide.
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