At-Risk Populations for Osteosarcoma: The Syndromes and Beyond

Table 1

Osteosarcoma predisposition syndromes and their associated genes.

Syndrome	Inheritance	Genes	Gene product	Chromosome
Li-Fraumeni	AD	TP53	Tumor suppressor	17p13.1
Retinoblastoma	AD	RB1	Tumor suppressor	13q14.2
Rothmund Thomson II	AR	REQ4	DNA helicase	8q24.3
RAPADILINO	AR	REQ4	DNA helicase	8q24.3
Werner	AR	WRN	DNA helicase	8p12
Bloom	AR	BLM	DNA helicase	15q26.1
Diamond Blackfan	AD	RPS19, RPL5, RPL11, RPL35A,; RPS24, RPS17, RPS7, RPS10, RPS26	Ribosomal; Protein	Multiple