MicroRNA Involvement in Osteosarcoma

Table 1

List of microRNAs involved in regulation of OS.

MicroRNAs	Functions in OS	Expression level in OS samples	Analyzed OS samples	MicroRNA targets in OS	References
miR-34 family (miR-34a, 34b and 34c)	P53-related G1 arrest and apoptosis	Decreased	Cell lines and 107 tumor samples	CDK6, E2F3, Cyclin E2, BCL2	[30]
miR-31	P53-related cell proliferation	N/D	Cell lines	E2F2	[32]
miR-192, miR-215	P53-related cell cycle arrest	N/D	Cell lines	CDKN1A/p21	[31]
miR140	Chemoresistance to MTX and 5-FU	Increased in OS with chemoresistance	Mouse xenografts	HDAC4	[56]
miR-215	Chemoresistance to MTX	N/D	Cell line	DTL	[57]
miR-92a, miR-99b, miR-193a-5p, miR-422a	Discriminate good responders from poor ones	Increased	Cell lines and 27 paraffin-embedded samples	N/D	[59]
miR-132		Decreased
miR-21	Cell invasion and migration	Increased	Cell lines and 8 tumor samples	RECK	[41]
miR-199a-3p	Cell proliferation and migration	Decreased	Cell lines and 12 tumor samples	MET, mTOR, STAT3, MCL-1, BCL-X	[43]
miR-143	Pulmonary metastasis	Decreased in OS with metastasis	Cell lines and 22 tumor samples	MMP-13	[46]

Abbreviation: N/D, no data; MTX, methotrexate; 5-FU, 5-Fluorouracil.