Table 1: Embryonic signaling pathways in rhabdomyosarcoma.

Embryonic pathwayMechanismReference

Notch(i) Promotes proliferation, suppresses differentiation, and avoids irreversible cell cycle arrest[18]
(ii) Promotes invasiveness and mobility[19]
(iii) Promotes proliferation and suppresses differentiation[20]

WNT(i) Suppresses differentiation and resists apoptosis[21]
(ii) Promotes proliferation and resists apoptosis[22]

Hedgehog(i) Promotes proliferation[23]
(ii) Suppresses differentiation[24]