“Malignant” Perivascular Epithelioid Cell Neoplasm: Risk Stratification and Treatment Strategies

Table 2

Univariate analysis of clinical and histologic factors related to PEComa-NOS recurrence.

Variable	Recurrence rate	Risk ratio	95% CI	𝑃-value
Age (continuous variable)		1.02	1.01–1.04	0.01
Size
< 5 cm	6/92 (6.5%)	1
≥ 5 cm	32/84 (38.1%)	10.74	3.22–66.47	<0.001
Sex
Male	10/37 (27.0%)	1
Female	28/134 (20.9%)	0.85	0.39–2.13	0.70
Mitotic rate
Low	7/93 (7.5%)	1
High (>1/50 HPF)	24/44 (54.5%)	10.0	4.00–30.30	<0.001
Grade
Grade 1-2	9/51 (17.6%)	1
Grade 3	8/19 (42.1%)	3.35	1.17–9.42	0.03
Necrosis
Absent	8/79 (10.1%)	1
Present	25/53 (47.2%)	7.19	3.18–18.38	<0.001
Vascular invasion
Absent	11/52 (21.2%)	1
Present	9/17 (52.9%)	3.22	1.19–8.49	0.02
Infiltration
Absent	5/24 (20.8%)	1
Present	7/38 (18.4%)	1.14	0.34–4.41	0.84
Primary location (versus all other sites)
GYN	12/42 (28.6%)	1.37	0.62–2.83	0.42
GI	4/22 (18.2%)	1.69	0.49–4.51	0.24
Skin	0/20 (0%)	6.2 × 10-7	NC	0.002
Liver/Falciform ligament	2/18 (11.1%)	0.34	0.05–1.14	0.09
Retroperitoneal	4/12 (33.3%)	1.32	0.39–3.40	0.61