Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma
Table 1
Prognostic relevance of clinicopathological variables for disease-specific survival in 206 non-gastrointestinal stromal tumor soft-tissue sarcomas (univariate analyses, log rank test, multivariate analyses, Cox proportional hazards model).
Characteristics
Univariate analyses
Multivariate analyses*
Patients ()
Patients (%)
Median survival (months)
5-year survival (%)
HR
95% CI
Age
0.030
0.121#
≤ 20 years
17
8
41
47
1.000
21–60 years
89
43
NR
61
0.728
0.281–1.889
0.515
>60 years
100
49
52
46
1.222
0.445–3.356
0.698
Gender
0.265
Male
89
43
NR
55
Female
117
57
75
51
Patient nationality
0.014
Norwegian
140
68
NR
58
1.000
0.142
Russian
66
32
39
42
1.453
0.882–2.393
Histological entity
0.003
0.086#
Pleomorphic sarcoma
54
26
54
48
1.000
Leiomyosarcoma
48
23
89
64
0.595
0.327–1.082
0.089
Liposarcoma
32
16
NR
71
0.411
0.169–0.999
0.050
Fibrosarcoma
16
8
123
56
0.773
0.330–1.808
0.552
Angiosarcoma
10
5
10
30
1.124
0.386–3.276
0.830
Rhabdomyosarcoma
12
6
41
50
0.419
0.156–1.126
0.085
MPNST
9
4
NR
56
0.544
0.162–1.824
0.324
Synovial sarcoma
13
6
31
28
1.257
0.571–2.767
0.570
Sarcoma NOS
12
6
9
25
1.640
0.707–3.805
0.249
Tumor localization
0.805
Extremities
79
38
123
56
Trunk
40
19
44
49
Retroperitoneum
30
15
57
47
Head/neck
16
8
27
47
Visceral
41
20
75
57
Tumor size
0.019
0.061#
≤5 cm
60
29
NR
66
1.000
5–10 cm
77
37
62
51
1.478
0.825–2.646
0.189
>10 cm
67
33
37
44
2.072
1.129–3.801
0.019
Missing
2
1
Malignancy grade
<0.001
<0.001#
1
56
27
NR
78
1.000
2
82
40
62
51
2.761
1.352–5.639
0.005
3
68
33
22
34
4.642
2.219–9.710
<0.001
Tumor depth
0.002
Superficial
16
8
NR
93
1.000
Deep
190
92
59
50
7.658
1.043–56.215
0.045
Surgery
<0.001
Yes
194
94
123
56
1.000
No
12
6
4
0
16.689
5.776–48.218
<0.001
Resection margins
<0.001
Wide
97
47
NR
66
1.000
Nonwide/no surgery
109
53
36
41
1.894
1.214–2.955
0.005
Chemotherapy
0.641
No
166
81
91
54
Yes
40
19
41
47
Radiotherapy
0.224
No
141
69
127
55
Yes
65
32
52
49
NR: not reached; MPNST: malignant peripheral nerve sheath tumor; NOS: not otherwise specified
*Only significant variables from the univariate analyses were entered into the multivariate analyses #Overall significance as prognostic factor.
