Clinical Study
Prognostic Impacts of Hypoxic Markers in Soft Tissue Sarcoma
Table 3
Tumor expression GLUT-1, HIF-1α, HIF-2α, and CAIX and their prognostic relevance for disease-specific survival in 206 patients with non-gastrointestinal soft tissue (univariate analyses; log-rank test, multivariate analyses; Cox proportional hazards model).
| Characteristics | Univariate analyses | Multivariate analyses* | Patients () | Patients (%) | Median survival (months) | 5-year survival (%) | | HR | 95% CI | |
| GLUT-1 | | | | | <0.001 | | | | Low expression | 110 | 53 | NR | 64 | | 1.000 | | | High expression | 83 | 40 | 28 | 42 | | 1.697 | 1.083–2.659 | 0.021 | Missing | 13 | 6 | | | | | | | HIF-1α | | | | | 0.658 | | | | Low expression | 77 | 37 | 91 | 54 | | | | | High expression | 123 | 60 | 80 | 54 | | | | | Missing | 6 | 3 | | | | | | | HIF-2α | | | | | 0.032 | | | | Low expression | 66 | 32 | NR | 62 | | 1.000 | | | High expression | 135 | 66 | 59 | 49 | | 0.965 | 0.581–1.603 | 0.892 | Missing | 5 | 2 | | | | | | | CAIX | | | | | 0.067 | | | | Low expression | 44 | 21 | NR | 65 | | | | | High expression | 162 | 79 | 58 | 50 | | | | |
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NR: not reached.
*Only significant variables from the univariate analyses were entered into the multivariate analyses.
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