Research Article
Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST
Table 1
Occurrence of different peripheral nervous system phenotype detected in various experimental and control cohorts.
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All mice were transgenic for Dhh-Cre. f/f: flox/flox; f/+: flox/+; : total number of mice in each cohort; Median: median survival age; : number of mice examined for the occurrence of various peripheral nervous system phenotype; DRG: number of enlarged dorsal root ganglia isolated (mean ± standard deviation); Grade: tumor grade was determined by histological evaluation as described in Section 2. High: high-grade PNST; Low: low-grade PNST; Hyperplasia/Low: hyperplasia to low-grade PNST. Percentage of animals in each cohort that displayed the following peripheral nervous system phenotype; BP: enlarged brachial plexi; TN: enlarged trigeminal nerves; SN: enlarged sciatic nerves; LP: enlarged sacral plexi. |