Review Article

The Genetics of Osteosarcoma

Figure 1

Frequent chromosomal aberrations in sporadic conventional osteosarcoma. Green highlighted areas represent minimal common regions of gain and amplification, or cytobands containing frequently gained and amplified genes. Red highlighted areas represent minimal common regions of loss, or cytobands containing genes frequently lost. Refer to Table 1 and the text for more details regarding minimal common regions and the presence of genetic mutations in some areas of the genome. Chromosome images adapted from the Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer (http://cgap.nci.nih.gov/Chromosomes/Mitelman/. Accessed January 25, 2012).
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