Survival Trends and Long-Term Toxicity in Pediatric Patients with Osteosarcoma

Table 1

Distribution of prognostic factors over three decades.

Prognostic factor (𝑁)	1979–1983	1984–2002	2003–2008	𝑃
	𝑁=29	𝑁=59	𝑁=42
Metastases at diagnosis	24.1% (7)	25.4% (15)	16.7% (7)	0.58
Tumor in axial skeleton	6.9% (2)	8.5% (5)	4.8% (2)	0.51
Good histologic response	24.1% (7)	23.7% (14)	35.7% (15)	0.55
>15% reduction due to toxicity	24.1% (7)	20.3% (12)	7.1% (3)	0.04