Global Gene Expression Profiling of Human Osteosarcomas Reveals Metastasis-Associated Chemokine Pattern

Figure 2

Hierarchical clustering of all primary tumours based on the top-20 significant genes differentially expressed between primary samples from patients who developed metastases and those who did not, identified by SAM analysis (one primary tumour with no clinical information on metastases was excluded). Samples coloured in lilac, primary samples from patients who later developed metastases; green, primary samples from patients who did not develop metastases. Red, increased gene expression; green, decreased gene expression. The cluster was made using average linkage and Pearson’s correlation.